The mechanism of cholesterylester accumulation in smooth muscle cells was investigated.
2
When membrane cholesterol levels are low, absorption of cholesterol effectively drives cholesterylester hydrolysis.
3
This difference is consistent with reports of the nonendocytotic selective uptake of HDL-associated cholesterylester.
4
Unexpectedly, cholesterylester transfer protein was not required to determine the human-like cholesterol lipoprotein profile.
5
Our results demonstrate that lysosomal hydrolysis of cholesterylester is independent of the presence of extracellular acceptors.
1
However, implication of LXRs in the selective uptake of cholesterylesters from lipoproteins in human macrophages has never been reported.
2
A simple method has been developed for labelling human plasma lipoproteins to high specific radioactivity with radioactive cholesterylesters in vitro.
3
They serve to transport endogenously synthesized lipids, mainly triglycerides (but also some cholesterol and cholesterylesters) to peripheral tissues.
4
Lysosomal acid lipase (LAL) is a key enzyme that cleaves cholesterylesters and triglycerides to generate free fatty acids and cholesterol in lysosomes.
5
Inhibition of ACAT, the enzyme which catalyses the intracellular formation of cholesterylesters, is a very attractive target for the treatment of hypercholesterolaemia and atherosclerosis.
1
This occurs through the maintenance of caveolae cholesterol content by cholesterolester uptake from HDL.
2
Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterolester between lipoprotein particles.
3
Conclusions: The authors concluded that FEL irradiation can remove cholesterolester selectively from human atheromatous CA plaques.
4
In the absence of active LPL in the same tissue, inactive LPL only mediates selective cholesterolester uptake.
5
We observed abnormal hepatic accumulation of cholesterol in the homozygote individuals, supporting the diagnosis of cholesterolester storage disease.
Uso de cholesterol esters em inglês
1
The process begins with a vascular injury that is complicated by the deposition of cholesterolesters and cholesterol.
2
Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterolesters and phospholipids were examined.
3
On the other hand, an EPA-rich diet produced a marked increase of this fatty acid, especially in cholesterolesters.
4
In contrast, the incorporation of exogenous oleate into secreted triacylglycerols and cholesterolesters was unaffected by deficiency of ABHD5.
5
The cholesterol ester transfer protein (CETP) facilitates the transfer of HDL cholesterolesters from plasma to the liver.
6
In cholesterolesters, however, arachidonic acid was significantly decreased and eicosapentaenoic acid appeared increased only to a low level of significance.
7
The lipid modules comprising phospholipids, triglycerides, sphingolipids and cholesterolesters were correlated with AD risk loci involved in immune response and lipid metabolism.
8
Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterolesters and triglycerides, SCD is pivotal in fatty acid metabolism.
9
The purpose of this study was to determine the effectiveness of infrared free-electron laser (FEL) irradiation of cholesterolesters in human carotid artery (CA) atheromas.